in spite of ~; undaunted by ~; in defiance of ~; in face of ~
Despite severe physical handicaps, she took charge of her own life.
Undaunted by his inability to speak Japanese, he traveled around Japan communicating with gestures and signs.
Overcoming high waves, my friend swam (all of) four kilometers.
I put all the examples along with the meaning into flashcards to study just in case you forget. (I suggest downloading the app version for brainscape) With this you can even study on your phone!
Feel free to use this flash card deck I update regularly.
This grammar is really for intermediate-advanced learners. If you are looking to know where to start in Japanese and building a good foundation check out this blog post it.